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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ITIH4 All Species: 11.21
Human Site: Y469 Identified Species: 30.83
UniProt: Q14624 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14624 NP_002209.2 930 103357 Y469 L T A V T F E Y P S N A V E E
Chimpanzee Pan troglodytes XP_516522 930 103281 Y469 L T A V T F E Y P S N A V E E
Rhesus Macaque Macaca mulatta XP_001085586 930 102291 Y469 L T A V T F E Y P S N A V E E
Dog Lupus familis XP_848765 826 91427 T379 V S L I I L L T D G D P T V G
Cat Felis silvestris
Mouse Mus musculus Q61704 889 99347 E442 F L E T L A L E N H G L A R R
Rat Rattus norvegicus Q63416 887 99079 A440 Y N F L E S L A L E N H G F A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508722 950 105792 E449 H V E F K F P E N T V L E L S
Chicken Gallus gallus XP_414253 886 99843 A439 Y N F L E K M A L E N K G L A
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_693183 963 108893 Y513 A L Q L Q G F Y E E V A T P L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.8 93.7 70 N.A. 38.8 39.5 N.A. 46.7 38 N.A. 37 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 99.4 97 78.7 N.A. 55.8 56.7 N.A. 61.3 57.6 N.A. 54.6 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 100 0 N.A. 0 6.6 N.A. 6.6 6.6 N.A. 13.3 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 26.6 N.A. 0 13.3 N.A. 13.3 13.3 N.A. 20 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 12 0 34 0 0 12 0 23 0 0 0 45 12 0 23 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 12 0 12 0 0 0 0 % D
% Glu: 0 0 23 0 23 0 34 23 12 34 0 0 12 34 34 % E
% Phe: 12 0 23 12 0 45 12 0 0 0 0 0 0 12 0 % F
% Gly: 0 0 0 0 0 12 0 0 0 12 12 0 23 0 12 % G
% His: 12 0 0 0 0 0 0 0 0 12 0 12 0 0 0 % H
% Ile: 0 0 0 12 12 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 12 12 0 0 0 0 0 12 0 0 0 % K
% Leu: 34 23 12 34 12 12 34 0 23 0 0 23 0 23 12 % L
% Met: 0 0 0 0 0 0 12 0 0 0 0 0 0 0 0 % M
% Asn: 0 23 0 0 0 0 0 0 23 0 56 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 12 0 34 0 0 12 0 12 0 % P
% Gln: 0 0 12 0 12 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 12 12 % R
% Ser: 0 12 0 0 0 12 0 0 0 34 0 0 0 0 12 % S
% Thr: 0 34 0 12 34 0 0 12 0 12 0 0 23 0 0 % T
% Val: 12 12 0 34 0 0 0 0 0 0 23 0 34 12 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 23 0 0 0 0 0 0 45 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _